The first generation antihistamines have been associated with side effects, particularly sedation.1 Second generation antihistamines are therefore favoured over the first generation drugs, not because of greatly improved efficacy but because they have fewer side effects, especially sedation.24 Although the second generation antihistamines are known to all have similar efficacy,3 the extent of their sedative effects is not well established.To further examine the sedative effects of four commonly prescribed antihistamines—loratadine, cetirizine, fexofenadine, and acrivastine—we analysed the results of four non-interventional observational cohort studies of these drugs performed by the Drug Safety Research Unit.These studies correlated prescriptions issued in general practice with events reported by the patients to their general practitioners after the drug was dispensed.
They may interfere with coordination and cloud your concentration.
Many sedating antihistamines do not require a doctor's prescription.
Because some can cause serious side effects or interact with other medications you are taking, be sure to let your doctor know all the medications you take.
Your doctor can guide you to the right antihistamine for you.
That means you can control your symptoms with only 1 or 2 doses each day compared with older medications, which usually require doses every 4 to 6 hours to maintain their effectiveness.