Maybe you want to prove to the world that you can make a full-blown Dating Sim without problems like illogical choices (or gratuitous sex).
Or perhaps you want to mix some relationship elements into your mainstream video game. The first decision you make will unlock a major Event Flag for your story/game: If you're not creating a product with the intention of selling it, then know what you're getting into.
The framework supports input of the alphabet, special characters, symbols, and even characters from other languages (as long as the font allows for it) into any Ren'Py game.
Documentation can be found on the Soft Keyboard page.
Any of them could have one or more transgendered people or bifauxnen as potential love interests.